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Output details

15 - General Engineering

Liverpool John Moores University

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Output 4 of 39 in the submission

Article title

Actin Bundling and Polymerisation Properties of Eukaryotic Elongation Factor 1 Alpha (eEF1A), Histone H2A-H2B and Lysozyme in vitro

Type

D - Journal article

DOI

10.1016/j.jsb.2011.09.004

Title of journal

Journal of Structural Biology

Article number

Volume number

176

Issue number

First page of article

370

ISSN of journal

1095-8657

Year of publication

2011

URL

Number of additional authors

Additional information

A stream of GERIs cell mechanics work, this paper represents a significant step in engineering knowledge applied to understanding how cancer leads to cells becoming mechanically compromised through actin disorganisation. The work involved using advanced microscopy techniques to quantify changes to actin structure. This multidisciplinary paper is important as it clearly established the link between organisation of the actin structure and mechanical integrity. It resulted in new international collaborations and in the development of a new French National Research Agency (ANR) project proposal to develop novel software tools that can be used to model actin organisation in cancer cells.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract