Output details

A pH-sensitive laser-induced fluorescence technique to monitor mass transfer in multiphase flows in microfluidic devices

Despite their apparent advantages, microsystems need to be scaled-up to reach industrially relevant production levels. To perform this step predictably detailed knowledge about the mass and heat transfer mechanisms on different length scales is needed. This work presents for the first time a non-invasive and high-resolution method to quantify interfacial mass transfer in gas-liquid flows on the micro-scale. This allowed identifying the physical mass transfer mechanisms and relating them to the individual reactor design and to the performance on larger scales. This knowledge found application within the Novartis-MIT Center for Continuous Manufacturing (Dr. Berthold Schenkel, Novartis Basel).