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11 - Computer Science and Informatics
University of East Anglia
A method for the analysis of domain movements in large biomolecular complexes
<28> We present DynDom3D, a method for determining domains and hinge axes given two structures of a biomolecule. It is part of the DynDom package, the foremost software for studying protein domain movements (see http://www.cmp.uea.ac.uk/dyndom/ and http://www.ccp4.ac.uk/) with the DynDom website and server receiving 700-800 visits per month. Here a significant advance in methodology is described which enables DynDom to be applied to any biomolecular complex. It is particularly suited for determining the presence of an allosteric mechanism. DynDom3D is part of the SBGrid Consortium software library at Harvard Medical School (see http://sbgrid.org).