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Anatomically Corresponded Regional Analysis of Cartilage in Asymptomatic and Osteoarthritic Knees by Statistical Shape Modelling of the Bone

<23> Establishing anatomical correspondence between structures visualised in medical images, over a population of individuals, is an essential step in analysing the effects of disease and/or therapy. This work is significant, because it shows that correspondence obtained automatically by optimising a minimum description length criterion is anatomically meaningful, and can be used to improve the statistical significance of image-based biomarkers. In collaboration with spin-out imorphics, the method has subsequently been used extensively in clinical trials and surgical planning applications by major pharmaceutical and orthopaedic companies across a range of disease/therapeutic areas (see impact case study).