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Spindles and active vortices in a model of confined filament-motor mixtures

<27>We developed a novel parallel numerical solver. The combination of equilibrium and novel non-equilibrium algorithms provides broad applicability in biophysics. We show that such simulations can yield important, otherwise inaccessible, quantities. Applied to cell dynamics, this paper was the first to replicate complex pattern (vortex) formation in isolates of cellular cytoskeleton, and provided a fundamental explanation of this long-standing puzzle. Enthusiastic responses evidenced by the journal editors' blog (30.01.2012), the MRC (http://bpod.mrc.ac.uk/archive/2012/3/7) and invited talks (e.g. BioScience2012). In follow-up work (with Gompper and Briels) we have extended the treatment to reproduce and understand recent cell extract experiments (submitted).