Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Manchester : A - Chemical Engineering
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Article title
Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes
Type
D - Journal article
Title of journal
Proceedings of the National Academy of Sciences of the United States of America
Article number
-
Volume number
105
Issue number
46
First page of article
17718
ISSN of journal
1091-6490
Year of publication
2008
URL
-
Number of additional authors
7
Additional information
This paper tests a high-risk hypothesis that I developed by looking at a parasite’s biochemistry as an engineer. The test was particularly hard, involved the experimental activities of my own, and other international laboratories, but was successful! The success is the basis for differential systems-biology based drug design strategy. It suggests a number of new targets in the regulatory mechanisms that prevent the turbo explosion in many cancer cells. It has served as prime example for the new disciplines of systems pharmacology, systems toxicology and systems physiology at vision meetings of leading scientists
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
