Output details
11 - Computer Science and Informatics
University of Edinburgh
Age-dependent Homeostatic Plasticity of GABAergic Signaling in Developing Retinal Networks
<28> Originality: This paper reports that spontaneous activity in the developing neural mouse retina is homeostatically stabilised against external perturbations during important developmental periods.
Significance: The first demonstration of this behaviour in an intact mammalian model. Establishes the retina as an easily accessible preparation to study neural homoestasis. Results follow from hypotheses developed in Hennig et al., J Neurosci (2009), and are a main outcome of Hennig's MRC fellowship.
Rigour: Validation of experimental results against two independent types of control experiment. Journal of Neuroscience is the most cited journal in neuroscience.
