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13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Central Lancashire
Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies†
This paper was highlighted in “New Therapeutic Approaches for Type 2 Diabetes: Small Molecule Approaches”, (ed. Robert M Jones, 2012, RSC Publishing, Cambridge, UK). Natural product pentacyclic triterpenes represent a promising class of multiple-target antidiabetic agents for diabetes management, which exert their hypoglycemic effects, in part, through GP inhibition. It is now evident that a number of pentacyclic triterpenoids have effects on glucose uptake, insulin secretion, diabetic vascular dysfunction, nephropathy and retinopathy, as presented in Alqahtani A et al., “The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications”, Curr. Med. Chem. 2013, 20(7), 908-931.