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11 - Computer Science and Informatics
University of Oxford
Programmable chemical controllers made from DNA
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This paper reports on experimental results about a new DNA computational architecture, previously presented by myself in a theory paper. It demonstrates an entirely new manufacturing technology for DNA computing, based on bacterially-produced plasmidic DNA, which bypasses inherent quality and length limitations of synthetic DNA. We demonstrate that this architecture can quantitatively emulate Chemical Reaction Networks, and we are therefore able to engineer any system that can be expressed as a finite set of chemical reactions with prescribed rates. That is, we can for the first time use chemistry as an executable programming language, as opposed to a modeling language.