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Structural variants of biodegradable polyesterurethane in vivo evoke a cellular and angiogenic response that is dictated by architecture

The evaluation of tissue-implant interactions when reporting in vivo studies is predominantly limited to qualitative descriptions. Here, we demonstrated the use of objective and reproducible methods based on stereology to quantify tissue-implant interactions. The high number of citations reflects the interest in the material – polyesterurethane, its in vivo biocompatibility and role in tissue engineering applications. It must also be highlighted that the fibre diameters of the electrospun membranes prepared in this study are about 10 times bigger than that possible with conventional electrospinning using solutions of most polymers. This in vivo study was supported by Enterprise Ireland funding.